8 results
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
cytochrome p450 CYP3A4 ... substrates to CYP3A4 ... interactions with the CYP3A4 ... inhibitors of CYP3A4 ... 4/291 #DOAC #CYP3A4
Amiodarone Toxicity and Monitoring

Tremor Ataxia 
Ocular neuritis 
Corneal Microdeposits 
Bradycardia 
Pulmonary fibrosis 
Hepatotoxicity 
Blue-gray skin
- Substrate CYP3A4
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
in the liver by CYP1A2 ... major), CYP2D6 and CYP3A4
PDE5 inhibitors are usually the drugs of first choice for erectile dysfunction.

PDE5 inhibitors enhance an erection that is
alpha blockers and CYP3A4
HIV Antiretroviral Pharmacokinetic Boosters - Ritonavir & Cobicistat 

Ritonavir & Cobicistat are 2 pharmacokinetic boosters used
They are both CYP3A4
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
Co-medication with CYP3A4
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
metabolized by CYP3A4
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Midazolam (Versed) - CYP3A4