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diagnosis differential endocarditis fungal infectiousdiseases microbiology infections causes infective morphology pathology bcnie betadglucan comparison galactomannan management yeasts abscess algorithm bacteria
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... bacilli - Fungi ... streptococci - Culture
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #negative #Endocarditis ... #CNIE #BCNIE #cardiology
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Staphylococci (skin), Gram-negative ... Staphylococci (skin), Gram-negative ... : Candida spp. ... (mucosa), Aspergillus ... : Aspergillus spp
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
Endocarditis (IE) Has Negative ... Blood Cultures ... negative IE - ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate
Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues Yeasts with Pseudohyphae: •
Consistent with Candida ... spp. however Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... septations #pathology #atlas
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture ... Negative Abscess ... as a cause of a negative ... culture Brain: ... Scedosporium, endemic fungi
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... remain negative ... fastidious bacteria or fungi ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
Cryptococcus, and Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... yeasts #fungal #fungi ... morphology #pathology #atlas
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... cell response to fungi ... exceptions are Aspergillus ... • India ink - "Negative ... #microbiology #microscopy
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... • Pathogens: Candida ... Coccidioides - Negative ... Cryptococcus - Negative ... closely related fungi
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