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diagnosis neurology oncology rheumatology apml barre capillary causes cerebritis clarksons cns dermatology differential differentiation disease dress emergencies erythematosus gitelman guillain
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... organ damage • Treatment ... acid, Elevated Cr ... TLS #diagnosis #management ... #hematology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment Stop offending agents: • List as allergies
Symptoms (DRESS) Syndrome ... Treatment Stop ... LFTs daily • Cr ... #Treatment #Management ... #dermatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... common • Imaging: CXR ... APML #diagnosis #management ... #hematology #oncology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... - Fever - Tachycardia ... ) • AKI: BUN/Cr ... Differential #Diagnosis #Management ... #nephrology
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... urinary retention, tachycardia ... Treatment: • Plasmapheresis ... #diagnosis #management ... #treatment #neurology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Puncture, EEG Treatment ... #rheumatology # ... cerebritis #diagnosis #management ... #treatment
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... , hypotension, tachycardia ... edema, compartment syndrome ... #diagnosis #management ... #rheumatology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
): - Hematologic ... interventional radiology ... → no immediate treatment ... - Occurs after CAR-T ... speech changes (CAR-T
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... • Ventricular tachycardia ... Rhabdomyolysis Treatment ... #diagnosis #nephrology ... #management #pathophysiology
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