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diagnosis causes differential management algorithm growthhormone acromegaly coagulation dic feedbackloop hematology intravascular overproduction pediatrics pituitary rhabdomyolysis shortstature signs summary symptoms
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... GH excess after ... overgrowth: • Carpal ... signs #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... excess: - ... expansion (e.g. carpal ... #FeedbackLoop #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... excess occurs before ... pseudo-acromegaly, obesity, hypothyroidism ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Tall Stature - Differential Diagnosis Algorithm Normal Growth (BA=CA) • Familial Tall Stature • XYY Syndrome Obese BMI
Puberty Onset • GH ... Excess • Hyperthyroidism ... Precocious Puberty • Adrenal ... • Congenital Adrenal ... Diagnosis #Algorithm #endocrinology
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Cushing's Disease • GH ... Dwarfism) • Hypothyroidism ... • Congenital Adrenal ... Panhypopituitarism Treatment ... Diagnosis #Algorithm #endocrinology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Metabolic myopathies, Excess ... Endocrine (Hypo/Hyperthyroidism ... Dermatomyositis) AKI - Pathophysiology ... oxidative iniury Treatment ... Summary #causes #treatment
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... protein C and S Pathophysiology ... Bleeding (64%) • Renal ... + Bleeding Treatment ... diagnosis #causes #treatment
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