28 results
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... • unicentric, HHV8 ... associated with Castleman's ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation
Kaposi sarcoma (KS):
 • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... Light chain: - HHV8 ... + Multicentric Castleman ... de Fremont #HHV8
Unicentric Castleman Disease (UCD) vs Multicentric Castleman Disease (MCD) - Comparison Table

Unicentric Castleman Disease (UCD):
 •
Unicentric Castleman ... vs Multicentric Castleman ... Associated with HHV ... Associated with HHV ... association: Yes, in HHV
CASTLEMAN DISEASE
Disorder of the immune system with excessive production of IL-6

Castleman’s disease is a rare, heterogeneous
CASTLEMAN DISEASE ... herpesvirus-8 (HHV ... especially in HHV ... Serologies: Testing for HHV ... is crucial, as HHV
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... , Multicentric Castleman ... activity against HHV ... adjunctive therapy #HHV8 ... KaposiSarcoma #Castlemans
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV-multicentric Castleman ... diagnosis #management #hhv8
Pathology - Castleman disease. 

Mediastinal mass in a younger woman.

Histologic Features of Castleman disease, hyaline vascular
Pathology - Castleman ... Histologic Features of Castleman ... @mjcascio #Castleman
Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV ... Herpes #Viruses #HHV
Lymphadenopathy - Differential Diagnosis Algorithm
Localized: 
 • Cervical: EBV, CMV, HIV, Toxo, TB, Lymphoma, Head /
Miscellaneous: Castleman's
Kaposi Sarcoma Herpes Virus (KSHV)

By Dr. Sara Dong @swinndong via #IDFellowCase
#ID  #Infectious Diseases  #Infections
#Differential
Diagnosis #KSHV #HHV