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diagnosis signs sle erythematosus neurology systemic treatment classification druginduced hematology infections infectiousdiseases syndrome adultonset agglutinin aids ana anemia antibodies antinuclear
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... 40, F:M 9:1 • Clinical ... Evolution: Chronic disease ... #Summary #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... likely it will be clinically ... ANA #patterns #rheumatology ... #diagnosis #differential
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... constitutional symptoms ... Evolution: Chronic disease ... comparison #table #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... pain (20%) Renal disease ... haemolytic Coombs positive ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... fraction < 20% Differential ... • Ocular: uveitis ... #diagnosis #management ... #treatment #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Skin lesions • Positive ... ) Differential Diagnosis ... Syndrome #diagnosis #management ... #signs #symptoms ... #rheumatology #
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Optica (NMO) - Clinical ... desaturation, Scotoma, Ocular ... complications (AQP4-positive ... disorders (Systemic lupus ... diagnosis #neurology #symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Erythematous, macular ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... : • Symptoms limited
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
worsening of that disease ... initiation Clinical ... skin lesions, ocular ... Zoster flare, ocular ... #Diagnosis #Management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... Others: • Lupus ... such as systemic lupus ... Presentation - Systemic Symptoms ... #diagnosis #rheumatology
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