18 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, fever, joint pain ... , bleeding, infections ... Lymphadenopathy • HSM • Fevers ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Subacute-Acute: • Common: fever ... effusions, weight gain ... initiation • Differential ... Diagnosis: Infection ... #hematology #oncology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
parvovirus B19 infection ... parvovirus B19 infection ... • Rheumatic fever ... #skin #rashes #differential ... #diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... Diagnosis Framework ... • Rheumatic fever ... #Differential # ... Diagnosis #MSK #
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Malar rash 40% - Fever ... ) 30-45% Differential ... Other auto-immune, Infectious ... symptoms #mimickers #differential ... #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... search ANA and aPL ... 9) Unexplained fever ... , when infection ... erythematosus #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Bacterial or viral infection ... Cardiomyopathies - Viral infection ... conditions #joint #pain ... #differential # ... diagnosis #rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
- Pel-Ebstein fever ... Alcohol-induced pain ... : Pain in involved ... #differential # ... hematology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... - Diagnostic Framework ... acute rheumatic fever ... #rheumatology # ... approach #workup #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
younger pts) Differential ... Symptoms: High fevers ... chills, flank pain ... hemolytic #anemia #hematology ... #diagnosis