45 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
Kayexelate #Comparison #Table ... #Pharmacology # ... Patiromer #HyperKalemia ... #Nephrology #Agents
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... Heparin) • Sodium-channel ... • Increased EC ... differential #diagnosis #pathophysiology ... #pharmacology #
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
, Hypokalemia, Erectile ... potential Ca2+ channel ... failure Ca2+ channel ... Pgp-dependent drugs (e.g ... contraindications #table
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia.
 - At
Hyperkalemia shortens ... repolarization; changes ... #Diagnosis #Hyperkalemia ... #EKG #ECG #Changes ... #Progression #Table
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
S - Shock H - Hyperkalemia ... Typical ECG ... other findings of hyperkalemia ... • If on a Ca2+ channel ... diagnosis #management #pathophysiology
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Decreased ENaC channel ... happypillsrx/ #Hyperkalemia ... #Pathophysiology ... #Pharmacology #
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... Sites #Action #nephrology ... #pharmacology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Agents to Treat Hyperkalemia ... to moderate); hypokalemia ... • Mechanism: Exchanges ... #medications #pharmacology ... #table #comparison
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
- Cognitive Changes ... Serotonin #Inhibitors #Pathophysiology ... #Pharmacology # ... Diagnosis #Signs #Symptoms
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... function • Minimal Change ... hyporenin hypoaldo, hyperkalemic ... KidneyDisease #nephrology ... #Effects #pathophysiology