16 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... malignancies • Infection ... Myelofibrosis Stem cell ... Toxins • Aplastic Anemia ... #Differential #
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... - infiltrates (anemia ... or functional neutropenia ... #Leukemia #Hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Basophilia - Differential ... released during an allergic ... reaction or asthma ... Disorders: • Chronic ... ’s Disease • Asthma
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... histiocytosis • Allergic ... : Asthma, Eczema ... eosinophilia) • Infectious ... insufficiency, Chronic
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
(e.g. cancer, infection ... defects (e.g. sickle cell ... ), Infections, Hypersplenism ... Production #Index #hematology ... #anemia #differential
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... weeks without infection ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... #Chronic #Lymphocytic
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute infection ... malignancies • Anemia ... hemorrhage) • Chronic ... myeloid leukemia (CML
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Eosinophilia - Differential ... Rhinitis - Allergic ... Dermatitis - Asthma ... Primary: - CML ... Hypereosinophilic Syndrome - Chronic
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... hemolysis, deficiency anemia ... : Chronic infections ... post-splenectomy, Exercise, Allergic ... Thrombocytosis #Platelets #Differential
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... 5) Symptoms of anemia ... Complications: 1) Infection ... PRCA, autoimmune neutropenia