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causes algorithm hemolytic dermatology nonpalpable ttp workup bruising classification extravascular hemolysis hemolyticuremicsyndrome microangiopathy palpable petechiae petechial purpural purpuric rash rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
coagulation (DIC) - HELLP ... purpura (TTP), ... uremic syndrome (HUS ... #Causes #differential ... #diagnosis #hematology
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... #purpura #TTP # ... #thrombocytopenia ... #Comparison #Diagnosis ... #Table #Hematology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
with devastating differential ... algorithmic approach can help ... presents in thrombocytopenic ... , disseminated intravascular ... #Diagnosis #Dermatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP ... Syndrome • TTP/HUS ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - Hemolytic anemia ... : • DIC, TTP/HUS ... Diagnosis #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
(disseminated intravascular ... - Fanconi anaemia ... Bruising #Causes #peds ... #pediatrics #diagnosis ... #differential #
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... IVIG infusion Intravascular ... • MAHA: TTP, HUS ... , DIC, HELLP, AS ... classification #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... - DIC, TTP, HELLP ... , HUS, aHUS, mechanical ... #workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Purpura Activity ... reflection of intravascular ... WBC count and differential ... #Workup #Hematology
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