13 results
diagnosis pathophysiology rheumatology arthritis management rheumatoid endocrinology msk rankl signs symptoms table associations autoantibodies autoimmune bone bonetumors bony complications crp
Rheumatoid Arthritis Rheumatoid Arthritis (RA) is an inflammatory autoimmune condition. While chiefly thought of as a joint
TNF #CRP #RANKL #ostoblast ... #Citrullinated
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
relationship between osteoblasts ... marrow cells and osteoblasts ... RANK stimulates osteoclast ... projections from an osteoclast ... lysosomes in the osteoclast
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Factor (RF), Cyclic Citrullinated
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
IGFIR activates osteoblasts
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
anti-CCP (cyclic citrullinated
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... mos - yrs) • Osteoclast-osteoblast ... gentamycin - Toxic to osteoblasts
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
-> Anti-Cyclic Citrullinated
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
cells activate osteoblasts
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
RF) and cyclic citrullinated
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