Clarkes dermatology anemia classification hemolysis pathophysiology algorithm intravascular disease

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

anemia): ... cold agglutin disease ... #Hemolytic #Intravascular ... differential #diagnosis #hematology ... #anemia

Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

and Intravascular ... Diagnosis Algorithm ... anemia • ... Differential #Diagnosis #Algorithm ... #Causes #Hematology

Hemolytic anemia ... in Wilson's disease ... #Wilsons #Disease ... #hemolytic #anemia ... #Hematology #pathophysiology

Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

• Blood loss:

Iron Deficiency Anemia ... • Iron loss: Intravascular ... ) hemolysis, Intensive ... Structural: Celiac disease ... #ferritin #hematology

Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80

Differential Diagnosis Algorithm ... • Bleeding • Hemolysis ... #MCV #Classification ... Differential #Diagnosis #Algorithm ... #Causes #Hematology

Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies

Anemia Intrinsic ... Causes: • Liver disease ... IVIG infusion Intravascular ... Diagnosis #causes #classification ... #hematology

Red Blood Cell (RBC) Morphology Atlas
• Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning

, Liver diseases ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... , Disseminated intravascular ... #differential #hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... Differential Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology

Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
• Thalassemia

Algorithmic Approach ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Non-megaloblastic: Liver disease ... #MCV #Algorithm

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

• Symptoms of anemia ... anemia • Cold ... the RBCs causing intravascular ... #hemolytic #anemia ... #hematology #diagnosis

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