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diagnosis differential dermatology hairloss management rheumatology sle erythematosus focal nephritis nephrology systemic comparison criteria druginduced eularacr hair hematology hemoptysis high
Lupus Nephritis Primer Class I - Minimal Mesangial Class II - Mesangial Proliferative Class Ill - Focal Proliferative Class IV
Lupus Nephritis ... Primer Class I - ... IV - Diffuse Proliferative ... Nephritis #SLE #Classification ... #Classes #differential
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
renal histological evaluation ... : • Class I - ... mesangial LN • Class ... proliferative LN • Class ... Membranous LN • Class
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Differential Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... • Discoid lupus ... Differential #Diagnosis #Algorithm ... #causes
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... : Non-scarring alopecia ... > 0.5 g/24 hr, Class ... , Class Ill or IV ... #EULARACR #Classification
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Disease: Discoid lupus ... Diffuse Hair ... : Lupus erythematosus ... Scaling, pustules, crusts ... • Laboratory evaluation
Diffuse Hair Loss (Alopecia) - Differential Diagnosis Algorithm Scarring - Irreversible-biopsy required • Lupus erythematosus • Lichen
Diffuse Hair Loss ... Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... Psychological stress #Diffuse ... #causes
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... • Systemic Lupus ... Hodgkin's Lymphoma #Diffuse ... #Causes #Hematology
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Causes of Hemoptysis ... Differential Diagnosis Algorithm ... • Bronchitis Diffuse ... Vasculitis • Lupus ... #Causes #Pulmonary
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Photosensitivity, Alopecia ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... management of SLE • Evolution
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... cutaneous-DIL • Evolution ... Photosensitivity, Alopecia ... Positive in 60-80% of cases
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