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Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... • Vasculitis Coagulation ... deficiencies Coagulation ... Intravascular Coagulation ... Diagnosis #Algorithm #Causes
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... Diagnosis #Algorithm #Causes ... #Hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation ... is simultaneous coagulation ... Treat primary cause ... • Correct coagulation ... #diagnosis #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... disorders CAUSES ... • Secondary Causes ... Kasabach-Merritt syndrome Coagulation
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... HIT, ITP/HUS), Coagulation ... nonpalpable #palpable #Causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Congenital intrinsic coagulation ... Pre-analytical cause ... intravascular coagulation ... aPTT #Prolonged #Causes
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... intravascular coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... intravascular coagulation ... (DIC) • Anti-coagulation ... Diagnosis #Algorithm #Causes
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... aPTT #Prolonged #Causes ... differential #hematology #coagulation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... Extravascular #Causes
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