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diagnosis hematology differential algorithm causes cirrhosis product reactions acidosis aclf albumin barre chemistry chronic classification coagulation criticalcare dic disseminated diuresis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
for Albumin for Management ... ascites removed • Acute ... • Hepatorenal syndrome ... #Cirrhosis #treatment ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... intestines, white blood ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Skeletal muscle, cardiac ... Skeletal muscle, Cardiac ... intestines, White blood ... • Gilbert's syndrome ... #differential #Hepatology
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
Insufficiency, Liver ... Pneumothorax, Cardiac ... Abdominal compartment syndrome ... • Hypovolemic: Blood ... #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- ACS, AKI, acute ... lethargy, hematuria, cardiac ... with tetany or cardiac ... TLS #diagnosis #management ... #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... left heart 3-6 cardiac ... passage • Arterial blood ... ) on room air Treatment ... #treatment #hepatology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
irrigation • Management ... Torsemide) • Acute ... • Bleeding • Cardiac ... Prevention of blood ... Tolvaptan) • Treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... presents as an acute ... lymph node, or liver ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... ABO incompatible blood ... DIC • Severe Liver ... + Bleeding Treatment ... #management #hematology
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