17 results
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 90% - Low complement ... Discontinuation of causal ... 40, F:M 9:1 • Clinical ... 80% - Low complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... 40, F:M 9:1 • Clinical ... Positive in 60-80% of cases ... 80% - Low complement ... • Evolution:
Serious Bacterial Illness (SBI):
1) UTI and pyelonephritis
Most common cause of SBI
Accounts for 3-8% of uncharacterized fevers
Female
pyelonephritis Most common cause ... uncharacterized fevers ... Consider BCx, CSF evaluation ... presentation Urinalysis: LE ... Diagnosis #Peds #EM #Classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Erythematosus Clinical ... Constitutional domain: Fever ... anticoagulant • Complement ... #Criteria #SLE
Modified dengue severity classification, PAHO/WHO
Dengue without warning signs - DNWS:
 • Person who lives or has
dengue severity classification ... days and presents fever ... Shock or respiratory ... Shock evidenced ... bleeding: based on evaluation
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
of lactate as a clinical ... again we might see ... a multitude of clinical ... the appropriate clinical ... #typea #typeb #classification
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm
Structural Defect - Asplenia/HypospIenism
 • Bacteremia/Septic
Causes of Fever ... Bacteremia/Septic Shock ... Periodontal Disease Complement ... Infection #Fever ... #Causes #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... weight loss, and fever ... anti-Smith Ab, low complements ... Skin Disease Classification ... to: Arthritis, Fever
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
NETs), cytokines, complement ... COMMON CAUSES + ... CLINICAL RECOGNITION ... • Symptoms: Fever ... CLINICAL FEATURES
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... • Low serum C4 complement ... diagnosis #types #classification