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clinical diagnosis echocardiogram cardiology pericardial rheumatology ultrasound classification differential lung complex management pleural sle tamponade erythematosus pulmonary systemic typea vasculitis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Acute cutaneous lupus ... or pericardial effusion ... Class II or V lupus ... anticoagulant • Complement
Constrictive Pericarditis on POCUS Echocardiogram - Apical 3-Chamber View Young Lupus patient admitted to hospital new onset
Pericarditis on POCUS ... View Young Lupus ... could pinpoint the cause ... has pericardial effusion ... Lupus pericarditis
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 Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement
Constrictive Pericarditis on POCUS Echocardiogram - Subcostal View Young Lupus patient admitted to hospital new onset HFpEF.
Pericarditis on POCUS ... View Young Lupus ... could pinpoint the cause ... has pericardial effusion ... Lupus pericarditis
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 Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... cases, drug-dependent ... 90% - Low complement ... Discontinuation of causal ... 80% - Low complement
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Hemorrhagic Pericardial Effusions (Hemopericardium)- Differential Diagnosis Framework IATROGENIC DISEASE Secondary to invasive cardiac procedures NONIATROGENIC • Malignancy (e.g., metastatic spread:
Hemorrhagic Pericardial Effusions ... tuberculous pericardial effusions ... OTHER RARE CAUSES ... induced • MCTD, Lupus ... #Pericardial #Effusion
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... 80% - Low complement ... Lupusreference #SLE #lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Acute cutaneous lupus ... Lungs: • Pleural effusions ... RNP antibodies, Complement
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic lupus
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