392 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... Alternative Pathway #Complement ... Pathway #hematology #pathophysiology
Overview of the Complement System - Classical and Alternative Pathways

by Dr.Grace Leo @gracie_leo

#Complement #System #Classical #Alternative
Overview of the Complement ... gracie_leo #Complement ... Alternative #Pathways #Pathophysiology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal Syndromes ... anti-GBM) 10%: - Low Complement ... Antiphospholipid Syndrome ... Vasculitis - Normal Complement ... differentiation syndrome
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Irritable Bowel Syndrome (IBS) - Pathophysiology, Diagnosis and Management Algorithm
Risk factors: Previous acute enteric infection, Female
Irritable Bowel Syndrome ... (IBS) - Pathophysiology ... and Management Algorithm ... #Pathophysiology ... Diagnosis #Management #Algorithm
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Vasculitis #HUV #Pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings
Continued Innate Immunity
 • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... #Inflammation #pathophysiology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
staining (lg + complement ... MGPN • Complement ... of alternative complement ... MPGN without complement ... anti-phospholipid syndrome
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... Nephritic #Nephrotic #Syndrome ... #Comparison #Algorithm
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Differential Diagnosis Algorithm ... - Refeeding Syndrome ... Differential #Diagnosis #Algorithm ... potassium #low #pathophysiology