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management diagnosis rheumatology erythematosus systemic nephritis nephrology differential classification druginduced vasculitis criteria glomerulonephritis hematology medications pharmacology pulmonary summary syndrome thrombocytopenia
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... constitutional symptoms • Treatment ... Erythematosus (SLE ... 80% - Low complement ... life-threatening • Treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... 80% - Low complement ... life-threatening • Treatment ... #lupus #Systemic
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic Lupus ... ACUTE CUTANEOUS LUPUS ... anticoagulant - Low complement ... #Rheumatology #SLE
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... (SLE): Pathogenesis ... HLA-DR3 genes, complement ... #Systemic #Lupus ... Erythematosus #SLE
Immunosuppressive Medications in Systemic Lupus Erythematosus (SLE) - MTX (oral, subcutaneous) - AZA (oral) -
Medications in Systemic Lupus ... Erythematosus (SLE ... x 6–7 times) #SLE ... Medications #Systemic #Lupus ... Erythematosus #treatment
Algorithm for the Treatment of Membranous Lupus Nephritis Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the ... Treatment of Membranous ... Lupus Nephritis ... treat non-renal SLE ... treat extra-renal SLE
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Criteria for Systemic Lupus ... Acute cutaneous lupus ... anticoagulant • Complement ... Classification #Criteria #SLE ... #Systemic #Lupus
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... • Specific for SLE ... severe disease Treatment ... #Systemic #Lupus ... Erythematosus #SLE
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
cytoplasmic antibodies; SLE ... , systemic lupus ... Glomerulonephritis #Algorithm
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