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diagnosis differential management infectiousdiseases infections concurrent infective lung chronic msk neurology noninfective pathophysiology rash rheumatology acute antibiotic antibiotics antifungal arthritis
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
Causes of Fever ... Differential Diagnosis Algorithm ... • Infectious endocarditis ... Infection: • Fungal ... #causes
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Lipopolysaccharide components ... stranded RNA • Fungi ... Mannan and glucan components ... - Transport to brain ... transport across blood-brain
Systolic Murmurs - Differential Diagnosis Algorithm Benign / Flow / Hyperdynamic: • Pregnancy • Fever • Anemia Supravalvular
Differential Diagnosis Algorithm ... • Rupture • Endocarditis ... • Prolapse • Endocarditis ... Differential #Diagnosis #Algorithm ... #causes
ID Approach to Fever and Rash - Diagnostic Algorithm Central Maculopapular (most common): Measles, Parvovirus 819 / EBV,
ID Approach to Fever ... Rash - Diagnostic Algorithm ... Mycoplasma), Infective endocarditis ... Disseminated fungal ... Febrile #Diagnosis #Algorithm
Causes of Acute Onset Fever - Differential Diagnosis Algorithm Viral: • Rhinovirus • Influenza Virus • Parainfluenza
Causes of Acute ... Diagnosis Algorithm ... Infectious - Other: • Fungal ... Differential #Diagnosis #Algorithm ... #causes
Endocarditis Algorithm - Infective vs Noninfective Causes Noninfective: • Malignancy • Autoimmune disease • Systemic infection Native Valve
Endocarditis Algorithm ... vs Noninfective Causes ... Gram-negative bacilli • Fungi ... #Algorithm #Infective ... #Noninfective #Causes
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
Clinical features: Fever ... valves • MRI brain ... Clinical features: Fever ... in up to 30% of cases ... often seen • MRI brain
Causes of Encephalopathy - Differential Diagnosis Algorithm Hyperacute: - Primary Neurologic: Vascular (IS, ICH), Seizure, Migraine, Trauma
Causes of Encephalopathy ... Differential Diagnosis Algorithm ... Neoplasm-related (brain ... Inflammatory, Infectious (fungal ... #Causes
Major Brain Complications of Endocarditis Abscess: • May be macro or micro and occur at site of
Major Brain Complications ... of Endocarditis ... and recurrent fevers ... Ischemic stroke caused ... complications #brain
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
hypothalamus → fever ... Lipopolysaccharide components ... Double-stranded RNA • Fungi ... Mannan and glucan components ... Transport to brain
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