19 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... Renal Failure Treatment ... diagnosis #management #hematology
Treatment of Non-hepatitis C virus Cryoglobulinemia Vasculitis - French Vasculitis Study Group

MONOCLONAL CRYOGLOBULINEMIA (TYPE 1) 
IgM
Treatment of Non-hepatitis ... IgM monoclonal component ... IgG monoclonal component ... /or refractory disease ... Vasculitis #Management #Rheumatology
Pulmonary Nodule
Evaluation is guided by nodule size & assessment of probability of malignancy. In addition is
nodules (no solid component ... The treatment of ... disease and coronary ... artery disease; ... Larger solid components
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... autoinflammatory diseases ... hepatitis • Pulmonary ... diagnosis #management #treatment ... #rheumatology
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
Splenomegaly Treatment ... transformation into AML ... • Treatment is ... von Willebrand disease ... #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary
A defect in arterial oxygenation due to a gas exchange
cirrhosis • Intra-pulmonary ... perfusion scanning or pulmonary ... ) on room air Treatment ... diagnosis #management #treatment ... #hepatology
Portopulmonary Hypertension
Presence of pulmonary arterial hypertension in a patient with portal hypertension
No other obvious causes (chronic
Hypertension Presence of pulmonary ... (chronic lung disease ... , left heart disease ... pressure < 15mmHg TREATMENT ... diagnosis #management #hepatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cells can indicate disease ... microglobulin Treatment ... Transform to DLBCL, PML ... workup #oncology #hematology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... → no immediate treatment ... : - Seen with AML ... (~20 %) and APL ... renal failure, pulmonary
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... Syndromes #diagnosis #hematology