10 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... develop leukostasis syndrome ... smear: Blasts APML ... • Tumor lysis syndrome ... #Leukemia #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... #management #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Differential Diagnosis Algorithm ... Acute • Myloid (AML ... Amy Chung, MD, MSc ... #Disorders #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... age 70 years Symptoms ... transformation to AML ... progression to AML ... #diagnosis #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... suspicious clinical symptoms ... presence of metabolic syndrome ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... integrity of the blood-brain ... penetrance through the blood-brain ... • Depressive symptoms ... The clinical syndrome
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... Transform to DLBCL, PML ... workup #oncology #hematology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... peripheral nerve components ... normal CSF white blood ... than one after symptom ... the underlying pathophysiology
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... current treatment algorithm ... From Blood Cancer ... Myelodysplastic syndromes ... #algorithm #hematology