19 results
The protein complex mTORC1 is a convergence point for multiple signaling pathways that control cell growth
complex mTORC1 is a convergence ... network are many oncogenes ... Pathophys #mTOR #oncogenes
Convergence Retraction Nystagmus with a left 6th nerve palsy

Caused by a Midbrain hemorrhage

Dr. Boby Varkey Maramattom
Convergence Retraction ... @bobvarkey #Convergence
Hyperopia: Pathogenesis and clinical findings
 • Axial length of eye -> Short axial length of the
Decreased light convergence ... rays require less convergence ... rays require more convergence
Melanoma Pathogenesis

Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
that activate oncogenes
Parinaud's Syndrome
What?
 - Impaired upgaze
 - Light-near dissociation
 - Convergence retraction nystagmus
 - Eyelid retraction (Collier's
dissociation - Convergence
Parinaud's syndrome
What?
 • Light-near dissociation (tectal pupils)
 • Convergence retraction nystagmus
 • Eyelid retraction (Collier's sign)
tectal pupils) • Convergence
Hypophosphatemia - Differential Diagnosis Algorithm

Transcellular Shift
 • Recovery From DKA
 • Refeeding Syndrome
 • Acute Respiratory
Hypophosphatemic Rickets • Oncogenic
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
- High FGF-23: Oncogenic
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
therapy) • ↑FGF23: Oncogenic
Major Physiological Effects of Angiotensin II

Altered Peripheral Resistance
I. Direct vasoconstriction
II. Enhancement of peripheral noradrenergic
neurotransmission:
  A.
expression of proto-oncogenes