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diagnosis hematology differential management disease algorithm alternating anticoagulation antiphospholipid apml arterial autoimmune behcets bilateral bleeding bruising capillary cardiology clarksons clinical
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
platelet disorders, vascular ... Etiology: • Vascular ... Disruptions in vascular ... Streptococcus pneumoniae Vascular ... Differential #Diagnosis #hematology
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Mitochondrial myopathy, Muscular ... dystrophy, Myotonic
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... Cathepsin G release → vascular ... diagnosis #management #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperviscosity, TTP, APLS ... • Nephrotic Syndrome ... coagulation and other causes ... pathophysiology #hematology ... differential #diagnosis #vascular
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... : • Treatment: ... immunosuppressive meds) Vascular ... Behcets #disease #Syndrome ... #pharmacology #rheumatology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... Chediak-Higashi syndrome ... neutropenia in collagen vascular ... neutropenia in collagen vascular ... #hematology
Intermittent Bilateral Exophthalmos (Alternating Exophthalmos and Enophthalmos) on Physical Exam Observing this patient in silence for a
Treatments are aimed ... The syndrome of ... inflammatory, vascular ... Commonly, vascular ... Bilateral #clinical #video
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 SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... Rule out other causes ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management #Dermatology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... 150 published cases ... edema, compartment syndrome ... IVIg) • Limit vascular ... #rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome ... (APLS) Testing ... FOR TESTING: • Vascular ... maternal chromosomal causes ... Algorithm #diagnosis #hematology
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