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differential hematology algorithm iron management thrombocytosis b12 cobalamin embolism fatigue ferritin fever folate folicacid infections intermittent pathophysiology patterns periodic platelets
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD ... #Causes #differential ... #diagnosis #anemia ... #nutrition
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Loss (without anaemia ... Inflammatory Disease (IBD ... #differential #diagnosis ... #causes #nutrition
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... Crohn's > UC Anemia ... and IBD Pearls: ... IDA and active IBD ... /other causes •
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... Diagnosis Algorithm ... Tropical sprue, IBD ... Bypass surgery, Bacterial ... #ferritin #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Inflammatory: • IBD ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Ischemic Liver, IBD ... coagulation and other causes ... pathophysiology #hematology ... #differential #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Acute hemolysis, deficiency ... anemia, Rebound ... Vasculitides, IBD ... #Differential #Diagnosis
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
have hemolytic anemia ... folate that can cause ... with underlying mild ... #differential #diagnosis ... #hematology #nutrition
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... • Common Causes ... diarrhea related to IBD ... #diagnosis #management ... #nutrition
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
- Differential Diagnosis ... Still's disease • Crohn ... Non-Infectious Causes ... arthritis • Crohn's ... fever • Hyper-IgD
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