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differential management hematology algorithm iron dermatomyositis pathophysiology rheumatology anemia antimda5 antimda5dm antinxp2 antinxp2dm arterial ascorbicacid b12 bleeding bruising cancer cardiology
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Inflammatory Disease (IBD ... cancer) #Iron #Deficiency ... #differential #diagnosis ... #causes #nutrition
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD ... #Causes #differential ... #diagnosis #anemia ... #nutrition
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... UC Anemia and IBD ... IDA and active IBD ... fatigue w/ active IBD ... /other causes •
Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver
Causes of Fat Malabsorption ... • Autoimmune— Crohn's ... Pancreatic lipase deficiency ... Celiac disease • IBD ... #Causes
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... - Differential Diagnosis ... Inflammatory: • IBD ... malignancy • Iron deficiency ... #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... Arrhythmia - Too fast ... • Parenchyma: ILD ... Transverse myelitis • Hematology ... #differential #diagnosis
Iron Deficiency in Heart Failure Pathophysiology: Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... → Inflammation causes ... ng/mL (absolute ID ... 20% (functional ID ... #management #cardiology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... Ischemic Liver, IBD ... • COVID-19 • Fat ... coagulation and other causes ... #differential #diagnosis
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
folate that can cause ... with underlying mild ... folate deficiency ... #differential #diagnosis ... #hematology #nutrition
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... • Common Causes ... diarrhea related to IBD ... #diagnosis #management ... #nutrition
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