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Hypocalcemia - Workup Algorithm

Dr Nikhil Lohiya - NEPHKIDS 2020 @NEPHKIDS1

#Hypocalcemia #Workup #Algorithm #differential #diagnosis #endocrinology #causes
Hypocalcemia - Workup ... #Workup #Algorithm ... #differential #diagnosis ... #endocrinology ... #causes #calcium
Hypercalcemia Workup and Differential Diagnosis Framework
1) Determine whether PTH-dependent
2) Assess for other hormonal causes
3) Assess for
Hypercalcemia Workup ... and Differential Diagnosis ... #Workup #Differential ... #endocrinology ... #calcium
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Hypercalcemia ... histoplasmosis) • Milk (calcium ... #differential #diagnosis ... #calcium #high ... #endocrinology
Diagnostic algorithm for the workup of hypercalcemia. The diagnostic workup for patients presenting with hypercalcemia rests
for the workup ... The diagnostic workup ... Urine calcium-creatinine ... #Diagnosis #Hypercalcemia ... #Workup #Differential
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
Hypercalcemia Evaluation ... #workup #differential ... #diagnosis #endocrinology ... #calcium #elevated ... #evaluation #workup
Hypercalcemia - Differential Diagnosis Algorithm
Primary Hyperparathyroidism
 • Adenoma
 • Hyperplasia
 • MEN 1 and 2A
Tertiary Hyperparathyroidism
Differential Diagnosis ... Autosomal Dominant Calcium ... Other • Excess Calcium ... #Differential #Diagnosis ... #Algorithm #Endocrinology
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Hypercalcemia - ... Differential Diagnosis ... Bony Mets - Calcium ... #Differential #Diagnosis ... Algorithm #causes #endocrinology
Hypocalcemia Laboratory Evaluation

Serum levels of PTH, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D can help differentiate between
Hypocalcemia Laboratory ... disorders causing hypocalcemia ... Hypoparathyroidism - Calcium-sensing ... Hyperparathyroidism #Diagnosis ... #Endocrinology
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Hypocalcemia Workup ... - Differential Diagnosis ... #Workup #Differential ... #Diagnosis #Algorithm ... #nephrology #calcium
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Hypocalcemia - Diagnosis ... Syndrome - Calcium ... PTH Signaling #Hypocalcemia ... #Diagnosis #Management ... #endocrinology