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diagnosis management rheumatology neurology erythematosus hemophagocytic hlh immune iris lupus lymphohistiocytosis reconstitution sle systemic associated bandemia behcet cbc cerebritis cns
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI -
Syndrome (IRIS) ... - Pathophysiology ... factors: - Low CD4 ... duration or OI treatment ... #AIDS
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Puncture, EEG Treatment ... : • Inflammatory
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Syndrome - Overview ... of HIV/AIDS patients ... be present: • AIDS ... initiation Clinical ... #Syndrome #Differential
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... production of pro-inflammatory ... accumulation of clinical ... Assessment • Clinical
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Reversible course Differential ... epilepticus Treatment ... underlying cause • Treatment ... Seizures: Treat with AEDs
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... Disease (25-75%): Inflammatory ... (Clinical Dx). ... Behcet disease) Differential ... Arthritis, AS Treatment
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... abnormalities • Inflammatory ... #Bandemia #differential ... neutrophil #WBC #CBC ... #hematology #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... : The clinical ... syndrome of HAD ... Treatment: • HAART ... disorder #dementia #AIDS
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... photosensitivity, inflammatory ... permanent alopecia Differential ... Clinical Features ... vein thrombosis Hematologic
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
or triggers) is crucial ... Clinical Presentation ... Pathophysiology ... Overproduction of pro-inflammatory ... Diagnosis #Management #Hematology
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