1387 results
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
• SLE C3 ↓ C4 ... MCGN type 1 C3 ↓ C4 ... ↓↓ • Cryo C3 ... angiooedema C3 C4 ... • C3GN C3 ↓ C4
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Membranoproliferative • ↓C4 ... Cryoglobulinemia • Normal C3/C4 ... differential #diagnosis #nephrology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
, Anti-GBM, C3/C4 ... Differential #Diagnosis #nephrology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
decr of C3 and C4 ... Cryoglobulinemic #Nephrology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
anti-GBM ab, ANA, C3, C4 ... differential #diagnosis #nephrology
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Beta: C3 and C4
Staphylococcus-associated GlomeruloNephritis - Diagnosis and Management Summary
CLINICAL
 • Nephritic syndrome (Casts)
 • Marked proteinuria (may be
or CH50 • ± ↓ C4 ... GlomeruloNephritis #nephrology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Low C3 or low C4 ... Low C3 and low C4
Uremic Asterixis on Physical Exam

Dr. Arvind Canchi @arvindcanchi

#Uremia #Asterixis #PhysicalExam #clinical #video #neurology #nephrology
clinical #video #neurology ... #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Anti-ds-DNA, C3/C4 ... Differential #Diagnosis #nephrology