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Pleural Cryobiopsy

Dr. Udit Chaddha @udit_chaddha

#Pleural #Cryobiopsy #CryoBx #Pleuroscopy #clinical #video #Pulmonary
Pleural Cryobiopsy ... udit_chaddha #Pleural #Cryobiopsy ... #CryoBx #Pleuroscopy
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
• SLE C3 ↓ C4 ... MCGN type 1 C3 ↓ C4 ... ↓↓ • Cryo C3 ... angiooedema C3 C4 ... • C3GN C3 ↓ C4
Approach to the diagnosis of chronic hypersensitivity pneumonitis. 
*Consider additional test: bronchoscopy with bronchoalveolar lavage, transbronchial
transbronchial lung cryobiopsy ... transbronchial lung cryobiopsy
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Membranoproliferative • ↓C4 ... Cryoglobulinemia • Normal C3/C4
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Beta: C3 and C4
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Low C3 or low C4 ... Low C3 and low C4
Formation of Trunks and Cords of the Brachial Plexus
The spinal nerves of segments C5 – Th1
also of segments C4
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
, Anti-GBM, C3/C4
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Hypocomplementemia (C3 and/or C4
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
decr of C3 and C4