436 results
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... /dL) IgM MGUS, low-risk ... MGUS (IgG type, ... - protein <1.5 gm ... 8) light-chain MGUS
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Significance (MGUS ... Prevalence M > F MGUS ... IgM MGUS: • Serum ... MGUS: • Serum ... protein level (non-IgM
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Renal-centered (ie "MGRS ... • Organized Ig ... immunotactoid GN, Type I cryo ... #Significance #MGUS
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
Protein #Diagnosis #MGRS ... #MGUS #SPEP #IFE
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
formation is common in IgM ... Rouleaux #formation #IgM ... #gammopathy #MGUS
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... • MGCSMGRS ... Dermato-neuro syndrome) MGRS ... anemia due to cold IgG ... anticoagulant • IgM
Cryoglobulinemia Classification Types

Type 1: Monoclonal IgM (rarely IgG/lgA)
 • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
1: Monoclonal IgM ... may be seen when IgM ... 2: Monoclonal IgM ... 25%): Polyclonal IgM ... 3: Oligoclonal IgM
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... monoclonal #gammopathy #MGUS
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
notice there is an IgM ... The presence of IgM ... IgM anti-HBc is ... core antibody and IgM ... ) simply means IgM
Subtypes of Serum Proteins

Pre-albumin (Transthyretin)
Albumin
Globulins
 • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Transferrin • Gamma: IgM ... , IgG, IgA, RF,