1344 results
Gout: Pathogenesis and Clinical Findings
 - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders
 -
easily leaks into joints ... -> Uric acid crystallizes ... in a peripheral joint ... Neutrophils enter joint ... Hyperuricemia #Pathophysiology
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint ... 3) Number of Joints ... weight-bearing joints ... Number of Joints ... Inflammatory, crystalline
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Pathogenesis and Joint ... poly-articular joint ... Joint involvement ... space decr joint ... RheumatoidArthritis #RA #pathophysiology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders ... • Septic • Crystalline ... Lumbar Spine and SI Joints ... @AmyChung #Joint
Rheumatoid arthritis (RA): X-ray features
 • Soft tissue swelling (best seen by comparing left & right
together) • Joint ... closer to the joints ... ) • Joint Subluxations ... (Joint deformities ... Radiology #Clinical #Pathophysiology
Reactive Arthritis
 • Inflammation of joints (commonly large joints)
    - Asymmetric Oligoarthritis: Joint
Inflammation of joints ... commonly large joints ... Oligoarthritis: Joint ... pain in a few joints ... ReactiveArthritis #pathophysiology
Synovial Fluid Analysis:

Findings (COLOR	TRANSPARENCY	VISCOSITY	WBC COUNT (PER MM3)	PMN CELL COUNT (%)	GRAM STAIN	CULTURE	PCR TEST	CRYSTALS)

By Condition (Normal 
Noninflammatory 
Inflammatory:
Inflammatory: crystalline ... Arthrocentesis #Joint
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
and Degenerative joint ... Inflammatory Joint ... Swelling stimulates joint ... • Moving the joint ... JointPain #Diagnosis #pathophysiology
Rheumatoid Arthritis - 2020 ACR-EULAR Classification
≥ 6 of 10 points = definite RA
Joint Involvement:
= definite RA Joint ... 2-10 large joints ... , +/- large joints ... points >10 joints ... least 1 small joint
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
Stimulation of joint ... loading / use of joint ... Disruption of normal joint ... movement of the joint ... Osteoarthritis #OA #pathophysiology