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differential causes hepatology acidosis autoimmune decrease dm2 erythematosus false hba1c hemolysis hemolytic hepatic hepatitis hgba1c increase infections infectiousdiseases lactate lactic
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
• Asplenia Laboratory ... High Glucose Content ... • Hemolytic anemia ... HbA1c #HgbA1c #Laboratory ... Increase #Decrease #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Hypersplenism • AIHA ... #causes #classification ... #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
been reported (eg AIH-PBC ... , AIH diagnosis ... (rare) - IgG Elevation ... Necrosis) If mild laboratory ... #Hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... ALT and AST - Elevations ... deficiency - Anemia ... leads to chronic anemia ... #Laboratory #Diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... result in severe anemia ... immune hemolytic anemia ... Mild-to-moderate elevation ... #Workup #Hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
appropriate clinical context ... - assess other laboratory ... Arterial Oxygen Content ... 30mmHg) - Severe anemia ... #typea #typeb #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... Skin Disease Classification ... syndrome in the context ... : • AIHA 10% • ... lymphopenia, low PLT • Anemia
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Growers (Runyon Classification ... Growers (Runyon Classification ... Hematologic malignancy ... gastrointestinal symptoms (elevations ... Bone Marrow - Anemia
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