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My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... Negative Blood Cultures ... therapy - Number one cause ... of culture negative ... #Infective #Endocarditis
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... culture negative ... infective endocarditis ... #culture #negative ... #Endocarditis #
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Culture (+): ... staphylococci Culture ... Septic Emboli Cause ... • Blood cultures ... Treat underlying cause
Endocarditis Algorithm - Infective vs Noninfective Causes Noninfective: • Malignancy • Autoimmune disease • Systemic infection Native Valve
Endocarditis Algorithm ... vs Noninfective Causes ... • HACEK • Culture-negative ... amzn.to/2LmUODZ #Endocarditis ... #Noninfective #Causes
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... separate blood cultures ... but important causes ... Negative #Infective #Endocarditis
Streptocccus Pneumoniae Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative Epidemiology - 10% adult carriers: • Most common cause of:
• Most common cause ... media • Important cause ... peritonitis, and endocarditis ... sinus • Sputum culture ... Meningitis 10-14 days, Endocarditis
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Culture Positive ... Septic emboli cause ... Treat underlying cause ... #Endocarditis
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
dogs & latter can cause ... gram-negative bacillus cause ... to meningitis, endocarditis ... Myocarditis & culture-negative ... is difficult to culture
Duke's Criteria for Infective Endocarditis Definite IE - Pathologic Criteria: • Pathologic lesions - vegetation or intracardiac
for Infective Endocarditis ... demonstrating active endocarditis ... demonstrated by culture ... positive blood culture ... criteria #Infective #Endocarditis
Endocarditis checklist Initial evaluation • Peripheral blood cultures (three sets at three different sites) • Additional culture
Endocarditis checklist ... Peripheral blood cultures ... • Additional culture ... suspect right-sided endocarditis ... Critical Care #Endocarditis
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