11 results
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... 8.0 mg/dL • Potassium ... other symptomatic hypocalcemia ... treatment • Hypocalcemia
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Normal Acid-Base: Low ... Carbenoxolone, SAME, Cushing ... @priti899 #Hypokalemia ... Algorithm #causes #potassium
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Hypocalcemia Workup ... deficiency • Drugs: Calcium ... metastases, Hungry bone syndrome ... @aishaikh #Hypocalcemia ... #Workup #Differential
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... the basis of the potassium-to-creatinine ... ↓ Aldosterone: Cushing ... #hypokalemia ... #urine #potassium
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
priapism • Lab values ... WBC >100k, + lab signs ... sudden death • Lab values ... , Elevated Cr, Low ... hydration - Hyperkalemia
Causes of Hypocalcemia by Clinical Cause

Acute illness: pancreatitis, tumor lysis, severe illness - Secondary hyperparathyroidism from
Causes of Hypocalcemia ... pancreatitis, tumor lysis ... Family history of hypocalcemia ... Malabsorption syndrome ... hyperparathyroidism #Hypocalcemia
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pump - Digoxin works ... As a result, calcium ... - Hyperkalemia ( ... , in states of hypokalemia ... (or low potassium
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Family history of hypokalemia ... • Unexplained hypokalemia ... alkalosis • Normal or low ... pressure Labs: • Hypokalemia ... pathophysiology #Hypokalemia
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... previously stable values ... disorders including hypokalemia ... renal bruit or signs ... hormonal excess or hypokalaemia
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis ... reabsorption) Workup ... acidosis) • Low ... Treatments: • Calcium ... Management #Treatment #potassium