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diagnosis differential liver management transaminitis causes acute function gastroenterology interpretation tests aclf aih alcoholic anemia autoimmune chemistry cirrhosis diffuse drug
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... Cirrhosis • Chronic ... (>1000): • DILI ... Drug-induced liver injury ... #hepatology #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... e.g. ascites), Chronic ... hepatitis fibrosis ... #Diagnosis #Algorithm ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... 5-10x normal - Chronic ... Patterns #Liver #Injury ... #hepatology #LFTs ... #differential #diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular ... • Iatrogenic: DILI ... Ascariasis, Choledochal cyst ... #diagnosis #algorithm ... #hepatology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Underproduction Diagnostic ... Algorithm - Iron ... - Anemia of chronic ... disorder - TSH, LFTs ... #hematology #diagnosis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Function Test (LFTs ... abnormality vs bone Bili ... #FunctionTest #LFTs ... Transaminitis #diagnosis ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... : > 3 • Chronic ... liver #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
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