7528 results
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
in inflammatory cytokines ... and iron release Diagnosis ... #heartfailure #diagnosis ... #management #cardiology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
pro-inflammatory cytokines ... hemophagocytosis and cytokine ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Possible Approach to Immunosuppression in Severe COVID-19

The diagnosis and treatment of cytokine storm remains unknown and
COVID-19 The diagnosis ... and treatment of cytokine ... anticoagulation #COVID19 #management
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
of inflammatory cytokines ... 50% in nec fasc Diagnostic ... STSS #treatment #management ... #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine ... Presentation / Diagnosis ... Diagnosis via genetic ... Infection should be diagnosed ... #management #treatment
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Carcinoma (RCC) - Diagnosis ... and Management ... ), Recombinant cytokines ... Carcinoma #RCC #Diagnosis ... #Management #Summary
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology: • Cytokine ... opacities • Diagnosis ... • Differential Diagnosis ... Syndrome #APML #diagnosis ... #management #hematology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Endotoxins, Toxins, Cytokines ... Hyperthermia #comparison #diagnosis ... #management #treatment
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory Cytokine ... #Inflammatory #Cytokine ... Syndrome #Kaposi #diagnosis ... #management #hhv8
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... Auto-amplification loop Diagnosis ... hemophagocytosis = additional diagnostic ... Lymphohistiocytosis #diagnosis ... #management #treatment