2437 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... pro-inflammatory cytokines ... hemophagocytosis and cytokine ... Periodic fever syndromes ... Treatment: • Corticosteroids
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Endotoxins, Toxins, Cytokines ... production • Treatment ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... • Treatment:
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
Streptococcal Toxic Shock Syndrome ... of inflammatory cytokines ... necrosis STSS Treatment ... #Toxic #Shock #Syndrome ... #STSS #treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology: • Cytokine ... Renal Failure Treatment ... Differentiation #Syndrome
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... activation and cytokine ... • Bicytopenia Treatment ... diagnosis #management #treatment
Approach to Undifferentiated Shock - OnePager Summary
Shock occurs when there is inadequate blood flow (CO) &
essential to determine treatment ... CCB, BB, BRASH syndrome ... fat embolism, cytokine ... release syndrome
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Budd Chiari syndrome ... disease Imaging and Treatment ... ), Recombinant cytokines
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
proinflammatory cytokines ... anti-inflammatory cytokine
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Xanthomatosis • Cytokine ... secretion: POEMS syndrome ... , Syndrome Schnitzler ... cutis laxa, TEMPI syndrome
Hyperthermia Syndromes Comparison
Serotonin Syndrome - NMS - Malignant Hyperthermia - Malignant Catatonia
Cause - Onset - Vitals
Hyperthermia Syndromes ... Comparison Serotonin Syndrome ... Mental Status - Treatment ... #Hyperthermia #Syndromes