6522 results
Possible Approach to Immunosuppression in Severe COVID-19

The diagnosis and treatment of cytokine storm remains unknown and
COVID-19 The diagnosis ... and treatment of ... cytokine storm ... reasonable, but treatment
Streptococcal Toxic Shock Syndrome (STSS)
Complication of invasive GAS disease characterized by shock & MOF → occurs
of inflammatory cytokines ... 50% in nec fasc Diagnostic ... necrosis STSS Treatment ... Syndrome #STSS #treatment ... #management #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
activation and cytokine ... Presentation / Diagnosis ... Diagnosis via genetic ... • Bicytopenia Treatment ... #management #treatment
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
in inflammatory cytokines ... and iron release Diagnosis ... functional ID) Treatment ... #heartfailure #diagnosis
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Endotoxins, Toxins, Cytokines ... production • Treatment ... Serotonin syndrome • Treatment ... Hyperthermia #comparison #diagnosis ... #management #treatment
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology: • Cytokine ... opacities • Diagnosis ... • Differential Diagnosis ... Renal Failure Treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
pro-inflammatory cytokines ... hemophagocytosis and cytokine ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... Auto-amplification loop Diagnosis ... Unknown cause Treatment ... Lymphohistiocytosis #diagnosis ... #management #treatment
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Carcinoma (RCC) - Diagnosis ... disease Imaging and Treatment ... ), Recombinant cytokines ... Carcinoma #RCC #Diagnosis
Approach to Undifferentiated Shock - OnePager Summary
Shock occurs when there is inadequate blood flow (CO) &
essential to determine treatment ... fat embolism, cytokine ... Undifferentiated #Shock #diagnosis