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Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
Expected DAT Results ... Autoimmune Hemolysis DAT ... Hemolysis • DAT ... - ) WAIHA • DAT ... Drug-associated • DAT
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
blood smear + DAT ... Heinz bodies, DAT ... Sickle cells, DAT ... • Spherocytes, DAT ... • Spherocytes, DAT
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
- Antibody/DAT ... - Complement/DAT
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
IgG mediated - DAT ... IgM mediated - DAT
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Mixed-type AIHA (7-8%) DAT-negative
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
aPTT normal • DAT
Multifocal Atrial Tachycardia (MAT) • At least 3 different P wave morphologies: • Rate 100-180 • Irregular Etiology
Atrial Tachycardia (MAT ... ) • At least 3 ... #Tachycardia #MAT
INSULIN CONVERSION Total daily dose of insulin (TDD) =
divided doses a day ... insulin regimen at ... * 0.3 units/kg/day ... * 0.4 units/kg/day ... for a patient at
Multifocal Atrial Tachycardia (MAT) on EKG • Heart rate > 100 bpm (usually 100-150 bpm) •
Atrial Tachycardia (MAT ... intervals • At-least ... Visualmedapp #MAT
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
Characteristics at ... proteinuria - 3.5 g/day ... (%) • > 3g / day ... ml/min/1.73 m2 at ... • Dialysis at
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