13 results
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
rapidly develops (DIC ... ) Differential Diagnosis ... #Pregnancy #hepatology ... #obstetrics #obgyn ... #diagnosis #management
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Acute Fatty Liver ... Hemolysis, Elevated Liver ... schistocytes, DIC ... #HELLP #AFLP #obstetrics ... #hematology #diagnosis
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Hemolysis, Elevated Liver ... schistocytes, DIC ... #HELLP #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... Extrinsic Causes: • Liver ... IVIG infusion Intravascular ... MAHA: TTP, HUS, DIC ... classification #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
- Thalassemia, Liver ... , Disseminated intravascular ... coagulopathy (DIC ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
) • Advanced Liver ... Post-partum • Acute DIC ... Septic shock, Obstetric ... table #comparison #diagnosis ... #hematology #deficiency
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... DIC • Aminotransferases ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis ... #differential #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... • Severe Liver ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Disseminated intravascular ... coagulation (DIC ... Prolonged #Causes #diagnosis ... #differential #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
- Differential Diagnosis ... , disseminated intravascular ... disease • Acute DIC ... #Differential #Diagnosis ... #Hematology