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differential hemolysis aflp causes obstetrics pregnancy thrombocytopenia algorithm common comparison cvid extravascular fatty hemolytic hypogammaglobulinemia immunodeficiency immunology intravascular key liver
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology Atlas ... Myelodysplastic syndrome ... coagulopathy (DIC ... #key #diagnosis ... #differential #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... transplant • DIC ... macroangiopathic hemolytic anemia ... " • HELLP syndrome ... #hematology #hemolysis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP ... Syndrome • TTP ... /HUS • DIC • ... Algorithm #Causes #Hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... coagulation defects. 1) HELLP ... schistocytes, DIC ... AFLP #Obstetrics #OBGyn ... #Hematology #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
MAHA: TTP, HUS, DIC ... , HELLP - Grafts ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... #hematology #anemia
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
rapidly develops (DIC ... Preeclampsia, HELLP ... Liver #Pregnancy #hepatology ... #obstetrics #obgyn ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
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