26 results
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... I see all of these ... promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
NON-WEIGHT BEARING CHILD ... RED FLAGS - In all ... cell disease Rheumatology ... Algorithm #Pathway #Child ... #Peds #Pediatrics
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview: ALL ... , CML, AML, APML ... age • 75% of ALL ... distinctive primary granules ... #Leukemia #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- PNH - APLS ... Decreased Support Of Dermal ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
• Scleroderma renal ... • Catastrophic APLS ... differential #diagnosis #hematology
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Not all MAHAs are ... TMAs but (almost) all ... /o significant renal ... (catastrophic APS ... Microangiopathy #TMAs #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... Incidence: common in APL ... Anaphylaxis, Acute Renal ... unless severe APLS ... diagnosis #management #hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
cataracts, and renal ... of platelet α-granules ... differential #diagnosis #hematology
A quick infographic on various pearls about atopic dermatitis, a disease with an increasing burden on
the physical, mental ... dermatitis #eczema #dermatology ... Wigley AM, et al ... corticosteroids in dermatology ... Arch Dis Child.
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Features: POEMS, AL ... Cryoglobulinemia Renal-centered ... Differential #Diagnosis #hematology