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hematology anemia hemolytic management classification erythematosus lupus sle systemic vasculitis agglutinin algorithm antibody arthritis bandemia calculation causes cbc cold comparison
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... LDH • Anti-RBC autoantibodies ... type ± C3d • Blood ... smear: Differential ... management #treatment #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... Inflammatory #Myopathies #differential ... #diagnosis #comparison ... #rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Diagnosis Algorithm ... • Peripheral blood ... idiopathic, malignancy, autoimmune ... HTN) • Recent travel ... /Fevers, DAT (-)
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... #autoantibodies ... #signs #symptoms ... #mimickers #differential ... #rheumatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
long (in days) it takes ... • Hemolysis: Autoimmune ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... Diagnosis Framework ... noninflammatory Signs ... #Diagnosis #MSK ... #rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... CLL (older) • Autoimmune ... younger pts) Differential ... sensitize red blood ... Symptoms: High fevers
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... Corticosteroid use • Autoimmune ... cultures, including blood ... tachycardia or fever ... #WBC #CBC #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... • Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... rheumatologic diseases ... #Rheumatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch takes ... S/sx: Fever, flank ... RBCs (stored at 4C ... #Transfusions #diagnosis ... #management #hematology
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