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Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm Signs ... : Membrane defects ... #Differential # ... Diagnosis #Algorithm #hematology
Generalized Hyperpigmentation Differentials Use the Mnemonic "no skin SPARED" Images from dermnet.nz and merckmanuals Mnemonic from https://www.medscape.com/slideshow/dermatology-mnemonics-6011359#5 #diagnosis #differential
Hyperpigmentation Differentials ... the Mnemonic "no skin ... www.medscape.com/slideshow/dermatology-mnemonics ... #symptoms #signs ... #dermatology #skin
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... cardiac valve, vasculitis ... Algorithm #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... • Symptoms of anemia ... younger pts) Differential ... : High fevers, chills ... #hematology #diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... - Hemolytic anemia ... #Diagnosis #hematology ... #nonpalpable #dermatology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
semiology of Cutaneous Vasculitis ... • Drug-induced vasculitis ... #dermpath #dermatology ... #semiology #signs ... pathology #lesions #differential
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Skin Ulcers by Etiology ... insufficiency • Vasculitis ... • Bleomycin Hematologic ... • Sickle Cell Anemia ... ulcerative #skinrash #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. primary cold agglutin ... Intrinsic RBC Defects ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Butterfly rash, Vasculitis ... Restrictive lung defect ... ) Blood (75%): Anemia ... erythematosus #signs
Physiologic Skin Changes in Pregnancy - Differential Diagnosis Algorithm Face • Melasma Abdomen • Linea Nigra Hormone induced
Physiologic Skin ... in Pregnancy - Differential ... number (probable) Skin ... • Chadwick's sign ... #dermatology #Differential
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