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endocrinology agonists inhibitors dpp4 glp1 management metformin allopurinol cholinergic comparison gout indications medications overview pathophysiology prescribing receptor renal sglt2 sulfonylureas
Summary table of mechanism of action, side effect and contraindications of commonly used diabetic drugs. #pharmacology
Summary table of ... of action, side effect ... commonly used diabetic ... #pharmacology #dm2 ... #diabetes #medications
Sulfonylureas - Pharmacology Summary Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... Summary Mechanisms ... CKD Common Side Effects ... #Summary #DM2 # ... diabetes #endocrinology
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... disease Common Side Effects ... Toxicities: • GI side effects ... #Summary #DM2 # ... diabetes #endocrinology
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... Summary Mechanisms ... failure Common Side Effects ... #Summary #DM2 # ... diabetes #endocrinology
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Ozempic), or daily tablet ... pancreatitis Common Side Effects ... Toxicities: • Gl side effects ... #Summary #DM2 # ... diabetes #endocrinology
Metformin - First Line Treatment for Diabetes Type 2 • Start with initial dose of 500 mg
Treatment for Diabetes ... gastrointestinal (GI) adverse effects ... form and consider using ... Indications #Titration #Pharmacology ... #Diabetes #DM2
SGLT2 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors - Pharmacology ... Summary Mechanisms ... ) Common Side Effects ... • Euglycemic diabetic ... #Summary #DM2 #
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
titrate up to effects ... only few side effects ... #Pharmacology # ... Management #Diabetes ... #DM2 #Endocrinology
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
to treat Type 2 Diabetes ... Common side effects ... GLP1 #Agonists #Pharmacology ... #Dosing #Diabetes ... #DM2 #Endocrinology
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
Summary of actions ... CNS and cardiac effects ... • Reverses CNS effects ... Cholinergic #Agonists #Pharmacology ... #Table #Summary
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