13 results
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
leading to prolonged effects ... pharmacological effects ... by blocking the effects ... to block their effects ... #Pharmacology #
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
15 g QD • Side Effects ... 8.4 g • Side Effects ... daily • Side Effects ... #pharmacology # ... table #comparison
Metformin - First Line Treatment for Diabetes Type 2
• Start with initial dose of 500 mg
Treatment for Diabetes ... gastrointestinal (GI) adverse effects ... form and consider using ... #Titration #Pharmacology ... #Diabetes #DM2
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
to treat Type 2 Diabetes ... to the incretin effect ... Common side effects ... #Pharmacology #Dosing ... #Diabetes #DM2
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
- Pharmacology ... Ozempic), or daily tablet ... pancreatitis Common Side Effects ... Toxicities: • Gl side effects ... Summary #DM2 #diabetes
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... GLP-I receptor agonist ... failure Common Side Effects ... definitively cause/effect ... #Summary #DM2 #diabetes
Metformin: Biguanide
Metformin is the first-line medication for treatment of type 2 diabetes. It is very effective
the first-line medication ... treatment of type 2 diabetes ... point for side effects ... 2000 mg/day) and using ... #Metformin #Pharmacology
Pearls for Treatment of Alcohol Use Disorder

First-line pharmacotherapies for moderate to severe AUD include naltrexone and
acamprosate Common side effects ... well-known side effect ... achieve efficacy may hinder ... Screening #Addiction #Medications ... #Pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
Normal and Renal Dosing ... titrate up to effects ... only few side effects ... #Pharmacology # ... Management #Diabetes
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist
Dosing:
3 mg daily x 30 days, then 7 mg
Dosing: 3 mg ... drug to remain stable ... upset as a side effect ... #semaglutide #Diabetes ... #Pharmacology #