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endocrinology diabetes summary glp1 inhibitors management acromegaly antipsychotics cholinergic dmd duchenne features genetics mechanisms musculardystrophy oral pathophysiology psychiatry receptor renal
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
- Pharmacology ... GLP-I receptor agonist ... failure Common Side Effects ... definitively cause/effect ... #Summary #DM2 #
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
Normal and Renal Dosing ... titrate up to effects ... only few side effects ... #Pharmacology # ... Management #Diabetes #DM2
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Mechanisms and Side Effects ... -receptor agonism ... Antidepressant Effects ... #SideEffects #pharmacology ... #diagnosis #psychiatry
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
to the incretin effect ... Common side effects ... very similar to DPP4s ... #Pharmacology #Dosing ... #Diabetes #DM2
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
- Pharmacology ... Ozempic), or daily tablet ... pancreatitis Common Side Effects ... Toxicities: • Gl side effects ... Summary #DM2 #diabetes
Duchenne Muscular Dystrophy (DMD) The term "Muscular dystrophy" refers to a group of inherited progressive muscle disorders.
Affects 1 per 3500 ... occurs due to defects ... in the gene coding ... #Diagnosis #Features ... #Signs #Genetics
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg
Dosing: 3 mg ... drug to remain stable ... upset as a side effect ... empagliflozin and DPP4 ... semaglutide #Diabetes #Pharmacology
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
CNS and cardiac effects ... • Reverses CNS effects ... Edrophonium • Used for diagnosis ... #Pharmacology # ... Table #Summary
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Acromegaly: frontal bossing ... Macroadenoma direct effects ... multisystemic anabolic effects ... 2 adenoma mass effect ... agonist (Carbergoline
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