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diabetes summary diagnosis dpp4 glp1 inhibitors management acromegaly antipsychotics binding cholinergic comparison hyperkalemia mechanisms medications oral pathophysiology potassium psychiatry receptor
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Mechanisms and Side Effects ... • Binds to the ... releases, then re-binds ... Antidepressant Effects ... #SideEffects #pharmacology
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Ozempic), or daily tablet ... pancreatitis Common Side Effects ... Toxicities: • Gl side effects ... Summary #DM2 #diabetes ... #endocrinology
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... GLP-I receptor agonist ... failure Common Side Effects ... #Summary #DM2 # ... diabetes #endocrinology
Sulfonylureas - Pharmacology Summary Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... Mechanisms of Action: Binds ... CKD Common Side Effects ... #Summary #DM2 # ... diabetes #endocrinology
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
to the incretin effect ... Common side effects ... #Pharmacology #Dosing ... #Diabetes #DM2 ... #Endocrinology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
15 g QD • Side Effects ... 8.4 g • Side Effects ... daily • Side Effects ... #medications #pharmacology ... #table #comparison
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
titrate up to effects ... only few side effects ... #Pharmacology # ... Management #Diabetes #DM2 ... #Endocrinology
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
retention • Binds ... CNS and cardiac effects ... • Reverses CNS effects ... #Pharmacology # ... Table #Summary
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg
Dosing: 3 mg ... drug to remain stable ... upset as a side effect ... semaglutide #Diabetes #Pharmacology ... #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Acromegaly: frontal bossing ... Macroadenoma direct effects ... multisystemic anabolic effects ... agonist (Carbergoline ... Diagnosis #Management #Endocrinology
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