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diabetes comparison dm2 medications summary diagnosis glp1 acromegaly antipsychotics binding buprenorphine cholinergic dpp4 drugs hyperkalemia hypnotic inhibitors management mechanisms methadone
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Mechanisms and Side Effects ... • Binds to the ... releases, then re-binds ... Antidepressant Effects ... #SideEffects #pharmacology
Opioid Use Disorder Medications - Pharmacokinetics Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
leading to prolonged effects ... pharmacological effects ... by blocking the effects ... euphoric effects ... to block their effects
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
GLP-1 Receptor Agonists ... Ozempic), or daily tablet ... pancreatitis Common Side Effects ... Toxicities: • Gl side effects ... #Agonists #Pharmacology
Sedative-Hypnotic Drugs Benzodiazepines: - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
Dose-dependent depressant effects ... Dose-dependent depressant effects ... with few amnestic effects ... of anxiolytic effects ... #comparison #table
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... therapy with GLP-I receptor ... agonist • Personal ... failure Common Side Effects ... DM2 #diabetes #endocrinology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
15 g QD • Side Effects ... 8.4 g • Side Effects ... daily • Side Effects ... #medications #pharmacology ... #table #comparison
Summary of actions of some Cholinergic Agonists Bethanechol • Used in treatment of urinary retention • Binds
retention • Binds ... CNS and cardiac effects ... • Reverses CNS effects ... #Pharmacology # ... Table #Summary
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
GLP-1 Agonists ... to the incretin effect ... Common side effects ... #Pharmacology #Dosing ... Diabetes #DM2 #Endocrinology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist Dosing: 3 mg daily x 30 days, then 7 mg
Dosing: 3 mg ... drug to remain stable ... upset as a side effect ... semaglutide #Diabetes #Pharmacology ... #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Macroadenoma direct effects ... multisystemic anabolic effects ... Lanreotide) ± GH receptor ... Pegvisomant) ± D2 agonist ... Diagnosis #Management #Endocrinology
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